Milk derived peptides may adversely affect the biological health of humans by increasing the risk of dependency on insulin to overcome the occurrence of diabetes. The higher occurrence of the diabetes relies on the relationship of type 1 diabetes (T1D) and the consumption of variants A1 and B beta –casein from cow’s milk. The production of BCM-7 is more in A1 milk than A2 milk and the difference is basically due to position 67 of the beta casein chain. However, proline in A2 is substituted by  histidine in A1 milk casein chain. Deleterious effects of A1 milk in the process of digestion in human stomach and intestines

have not been reviewed earlier. It is an effort to review the aspect thoroughly and bring minor details into focus to have better understanding of the milk particularly in perspective of human health.